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Description

We found that mitochondrial dysfunction induced by palmitoyl-L-carnitine leads to calcium overload and activation of kinases that contribute to tau hyperphosphorylation

Hsieh C-H, Hsieh H-C, Shih F-S, Wang P-W, Yang L-X, Shieh D-B, et al

doi:10.1074/jbc.270.22.13399

These increases activated NRF2 and its downstream target HO-1 in a dose-dependent manner to attenuate the inflammation caused by IH in the pulmonary tissue (Wang et al